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A simple diagnostic index for asthma.

A Bansal1, J M Farnham, R O Crapo

  • 1Genetic Research, Intermountain Healthcare, LDS Hospital, 391 Chipeta Way, Salt Lake City, UT 84108, USA.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|June 26, 2001
PubMed
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Researchers developed brief questionnaires to screen for asthma phenotypes in adults and children. These tools efficiently identify potential asthma cases, reducing the need for extensive phenotyping in research settings.

Area of Science:

  • Pulmonary Medicine
  • Genetics and Epidemiology

Background:

  • Increasing prevalence of asthma necessitates research into its genetic and environmental factors.
  • Accurate phenotyping is crucial for understanding asthma's diverse presentations.

Purpose of the Study:

  • To develop a concise screening tool for asthma phenotyping in research.
  • To identify key questions for predicting asthma in diverse age groups.

Main Methods:

  • Eight symptom and history questions were administered to 678 adults and 244 children.
  • Logistic regression identified predictive questions, validated on separate cohorts.
  • Physician diagnosis and pulmonary function tests served as gold standards.

Main Results:

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  • A 3-question model for adults showed 0.94 sensitivity and 0.96 specificity.
  • A 2-question model for children achieved 0.97 sensitivity and specificity.
  • High negative predictive values (>0.87) and moderate positive predictive values were observed.

    • Conclusions:

    • Brief questionnaires serve as cost-effective preliminary screening tools for asthma research.
    • These tools can significantly reduce the number of subjects requiring detailed phenotyping.
    • Physician confirmation is recommended for "affected" calls due to varying positive predictive values.