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Endogenous retroviruses in the human genome sequence.
1Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, Cleveland Street, London W1T 4JF, UK. d.j.griffiths@ucl.ac.uk
Genome Biology
|June 26, 2001
Summary
Human endogenous retroviral sequences are abundant in our genome and may influence health and disease. Draft genome sequences offer a new way to study their precise roles.
Area of Science:
- Genomics
- Molecular Biology
- Genetics
Background:
- The human genome harbors numerous endogenous retroviral sequences (ERVs).
- ERVs are implicated in various physiological and pathological processes.
- Their exact functions remain largely undefined.
Purpose of the Study:
- To investigate the potential of draft human genome sequences for a more precise definition of endogenous retroviral sequence roles.
Main Methods:
- Analysis of draft human genome sequences.
- Bioinformatic identification and characterization of endogenous retroviral sequences.
Main Results:
- The draft human genome sequences provide a comprehensive resource for studying ERVs.
- This resource facilitates detailed analysis of ERV distribution and characteristics.
Conclusions:
- Draft human genome sequences are valuable tools for elucidating the functions of endogenous retroviral sequences.
- Further research using these sequences can clarify the involvement of ERVs in human biology and disease.