Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Executive dysfunction in Huntington's disease].

L Redondo Vergé1, R G Brown, J Chacón

  • 1Servicio de Neurología; Hospital Virgen de la Macarena, Sevilla, España. lredondov@meditex.es

Revista De Neurologia
|June 26, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An event-based adaptation of the relay feedback experiment for frequency response identification of stable processes.

ISA transactions·2023
Same author

Pattern Formation in a Spatially Extended Model of Pacemaker Dynamics in Smooth Muscle Cells.

Bulletin of mathematical biology·2022
Same author

Chlorophyll fluorescence decay profiles of O<sub>3</sub> -exposed spruce needles as measured by time-correlated single photon counting.

The New phytologist·2021
Same author

Numerical Bifurcation Analysis of Pacemaker Dynamics in a Model of Smooth Muscle Cells.

Bulletin of mathematical biology·2020
Same author

Robust switched control of an air levitation system with minimum sensing.

ISA transactions·2019
Same author

Prospective observational study of vaginal microbiota pre- and post-rescue cervical cerclage.

BJOG : an international journal of obstetrics and gynaecology·2019
Same journal

The Correlation Between and Variability of Three Balance Scales in the Assessment of Balance Function in Patients With Ataxia.

Revista de neurologia·2026
Same journal

Surgical Treatment of an Aneurysm in the Subacute Stage of Hemorrhagic Moyamoya Disease: Aneurysm Resection Combined With STA-MCA Bypass: A Case Report.

Revista de neurologia·2026
Same journal

Mapping the Evidence: Central Sleep Apnea Syndromes During Sleep and Stroke-A Scoping Review.

Revista de neurologia·2026
Same journal

Developmental and Epileptic Encephalopathy Due to a Novel <i>ARHGEF9</i> Deletion Variant: Case Series of Two Siblings.

Revista de neurologia·2026
Same journal

P300 Event-Related Potentials as Cognitive Biomarkers in Neurological and Neuropsychiatric Disorders: A Systematic Review.

Revista de neurologia·2026
Same journal

[Effectiveness and Risk of Recurrence of Pulsed Radiofrequency in Trigeminal Neuralgia and Chronic Cluster Headache].

Revista de neurologia·2026
See all related articles

Patients with Huntington's disease (HD) exhibit executive dysfunction, impacting attention and working memory. This cognitive decline is likely linked to fronto-striatal circuit dysfunction.

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Context:

  • Huntington's disease (HD) involves selective striatal neuron vulnerability.
  • Cortico-striatal circuits, particularly those involving the dorsolateral prefrontal cortex, are implicated in cognitive functions.
  • Early HD stages show cellular changes potentially leading to cognitive deficits.

Purpose:

  • To analyze and interpret executive dysfunction in moderately advanced Huntington's disease patients.
  • To investigate the cognitive impact of fronto-striatal circuit alterations in HD.
  • To assess specific cognitive domains affected in HD.

Summary:

  • 16 patients with Huntington's disease (HD) and controls were evaluated using clinical and cognitive scales (UHDRS, independence scale, total functional capacity, CAPIT-HD).

Related Experiment Videos

  • HD patients demonstrated significant deterioration in cognitive function, attention, and working memory tests.
  • Exceptions were noted in the WEST and direct order digit span tests.

    • Impact:

    • Confirms executive dysfunction in Huntington's disease (HD) patients.
    • Suggests fronto-striatal cognitive dysfunction as the most accurate descriptor for HD-related cognitive deterioration.
    • Highlights the role of cortico-striatal circuit dysfunction in HD pathogenesis.