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Rational design of a new series of pronucleotide
1UMR 5625 CNRS-UM II, Université Montpellier II, cc 008, place E. Bataillon, 34095 Cedex 05, Montpellier, France.
Abstract:
A new pronucleotide series is described involving a two-step degradation process mediated by, respectively, carboxylesterase and phosphoramidase. Taking AZT as nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in TK(-) cell line, which proves 5'-AZTMP delivery.
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