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A polymer-supported proline-based diamine catalyst for the kinetic resolution of racemic secondary alcohols
B Clapham1, C W Cho, K D Janda
1Department of Chemistry, Scripps Research Institute and, Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
The Journal of Organic Chemistry
|June 30, 2001
Abstract:
The preparation of polymer-supported proline-based diamine catalyst 12 for the kinetic resolution of racemic mixtures of secondary alcohols is described. Not only is the catalyst effective for the resolution of a host of different alcohols, it can also be recovered and reused several times without loss of either activity or selectivity. The catalyst has been used in conjunction with a polymer-supported sequestration strategy, giving rise to an essentially pure mixture of resolved products that can be separated using flash chromatography.