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Related Experiment Videos

Barnidipine.

H S Malhotra1, G L Plosker

  • 1Adis International Limited, Mairangi Bay, Auckland, New Zealand. demail@adis.co.nz

Drugs
|July 4, 2001
PubMed
Summary
This summary is machine-generated.

Bamidipine, a dihydropyridine calcium antagonist, effectively lowers blood pressure with a single daily dose. It demonstrates comparable efficacy to other antihypertensives and is well-tolerated, with fewer side effects like edema than amlodipine.

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Area of Science:

  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Bamidipine is a dihydropyridine (DHP) calcium antagonist used for hypertension.
  • It is formulated for modified release, allowing a single daily oral dose of 10-20 mg.

Purpose of the Study:

  • To evaluate the antihypertensive efficacy and tolerability of bamidipine.
  • To compare bamidipine with other antihypertensive agents and placebo.

Main Methods:

  • Clinical trials comparing bamidipine to other DHPs (nitrendipine, amlodipine), other drug classes (atenolol, enalapril), and hydrochlorothiazide.
  • Assessment of antihypertensive efficacy and adverse event profiles.

Main Results:

  • Bamidipine shows clinical antihypertensive efficacy similar to nitrendipine, amlodipine, atenolol, and enalapril.

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  • It is as efficacious and well-tolerated as hydrochlorothiazide in elderly hypertensive patients.
  • Adverse events like headache, flushing, and peripheral edema are typically transient and less frequent than with amlodipine or nitrendipine.

    • Conclusions:

    • Bamidipine is an effective and well-tolerated antihypertensive agent.
    • Its vasodilatory action reduces peripheral vascular resistance.
    • It offers a favorable side effect profile, particularly regarding edema, and does not cause reflex tachycardia.