Related Experiment Video

Updated: Aug 11, 2026

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient
11:17

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

Published on: November 3, 2009

Treatment of ocular toxocariasis with albendazole

T Barisani-Asenbauer1, S M Maca, W Hauff

  • 1Department of Ophthalmology, University of Vienna Medical School, Austria. talin.barisani@akh-wien.ac.at

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
|July 5, 2001
PubMed

Insights

Combined albendazole and steroid treatment effectively manages uveitis caused by Toxocara canis (ocular larva migrans syndrome). This therapy significantly improved visual acuity in all patients, with no recurrences observed.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Parasitology

Background:

  • Uveitis can be caused by parasitic infections like Toxocara canis.
  • Ocular larva migrans syndrome (OLM) presents a diagnostic and therapeutic challenge.

Purpose of the Study:

  • To evaluate the efficacy of combined albendazole and steroid treatment for Toxocara canis-induced uveitis.
  • To assess treatment outcomes in immunocompetent patients with OLM.

Main Methods:

  • Five patients with OLM underwent treatment with systemic albendazole and steroids.
  • Clinical manifestations, anti-Toxocara IgG, and Western blot confirmed the diagnosis.
  • Visual acuity, inflammatory response, and side effects were monitored post-therapy.

Main Results:

  • All patients experienced improved visual acuity, with mean Snellen acuity improving from 20/40 to 20/20.
  • No uveitis recurrences were noted during an average follow-up of 13.8 months.
  • The combined regimen was generally well-tolerated with no significant side effects reported.

Conclusions:

  • Albendazole combined with systemic steroids is an effective treatment regimen for ocular larva migrans syndrome.
  • This therapeutic approach offers a promising solution for managing Toxocara canis-induced uveitis.
  • Early diagnosis and prompt treatment are crucial for favorable visual outcomes in OLM patients.

More Related Videos

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...