Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retina01:32

The Retina

The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A 31-year-old man with cystoid macular edema of unclear origin].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2018
Same author

[Maculopathy with optic nerve pits : Morphological criteria in SD-OCT].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2017
Same author

[Primary enucleation in an avulsion injury : A high-risk procedure under phenprocoumon].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2017
Same author

[Materials/Biomaterials in Clinical Practice - a Short Review and Current Trends].

Zentralblatt fur Chirurgie·2015
Same author

[Challenges for Urologists in the Care of Patients with Lynch Syndrome: Example of A Patient with Muir-Torre Syndrome, A Subtype of Lynch Syndrome].

Aktuelle Urologie·2015
Same author

Response Properties of a Newly Identified Tristratified Narrow Field Amacrine Cell in the Mouse Retina.

PloS one·2015

Related Experiment Video

Updated: Jul 29, 2026

Single-cell Profiling of Developing and Mature Retinal Neurons
10:20

Single-cell Profiling of Developing and Mature Retinal Neurons

Published on: April 19, 2012

Cell-type specific dendritic contacts between retinal ganglion cells during development.

C Lohmann1, R O Wong

  • 1Department of Anatomy and Neurobiology, Washington University Medical School, Box 8108, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.

Journal of Neurobiology
|July 5, 2001
PubMed
Summary

Developing retinal ganglion cells (RGCs) form specific dendro-dendritic contacts. These contacts between same-sign RGCs, but not opposite-sign RGCs, may regulate mosaic formation and dendritic field overlap during development.

More Related Videos

Isolation of Primary Murine Retinal Ganglion Cells (RGCs) by Flow Cytometry
11:01

Isolation of Primary Murine Retinal Ganglion Cells (RGCs) by Flow Cytometry

Published on: July 5, 2017

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations
13:13

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations

Published on: March 19, 2021

Related Experiment Videos

Last Updated: Jul 29, 2026

Single-cell Profiling of Developing and Mature Retinal Neurons
10:20

Single-cell Profiling of Developing and Mature Retinal Neurons

Published on: April 19, 2012

Isolation of Primary Murine Retinal Ganglion Cells (RGCs) by Flow Cytometry
11:01

Isolation of Primary Murine Retinal Ganglion Cells (RGCs) by Flow Cytometry

Published on: July 5, 2017

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations
13:13

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations

Published on: March 19, 2021

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Retinal Cell Biology

Background:

  • Retinal ganglion cells (RGCs) process visual information within defined dendritic fields.
  • ON and OFF center RGCs form separate retinal mosaics with consistent overlap.
  • Lateral inhibition is hypothesized to regulate RGC dendritic field development.

Purpose of the Study:

  • To investigate the presence and nature of dendro-dendritic contacts between developing RGCs.
  • To determine if these contacts play a role in the formation of ON and OFF RGC mosaics.
  • To explore the cell-type specificity and developmental timing of these contacts.

Main Methods:

  • Multiphoton microscopy was used to reconstruct dye-filled, neighboring ON and OFF ferret alpha RGCs.
  • Dendro-dendritic contacts were analyzed across different neonatal ages.
  • Cell-type specificity of contacts was assessed by examining interactions between alpha and beta RGCs.

Main Results:

  • Dendro-dendritic contacts were observed exclusively between RGCs of the same sign (ON/ON or OFF/OFF), never between opposite signs (ON/OFF).
  • Contacts occurred between terminal dendrites and also involved fasciculation of dendritic processes.
  • Contacts were present before full stratification of alpha cell arbors, indicating early cell recognition.
  • Contacts were cell-type specific, with alpha cells not contacting beta cells of the same sign.

Conclusions:

  • Dendro-dendritic contacts between developing RGCs are cell-type specific and occur early in development.
  • These contacts likely mediate intercellular signaling crucial for regulating dendritic field extension.
  • Such signaling maintains constant relative overlap within ON and OFF RGC mosaics during development.