Solid-phase synthesis of peptidomimetic inhibitors for the hepatitis C virus NS3 protease
M A Poupart1, D R Cameron, C Chabot
1Department of Chemistry, Boehringer Ingelheim (Canada) Ltd., Quebec H7S 2G5, Canada.
The Journal of Organic Chemistry
|July 10, 2001
Abstract:
The NS3 serine protease enzyme of the hepatitis C virus (HCV) is essential for viral replication. Short peptides mimicking the N-terminal substrate cleavage products of the NS3 protease are known to act as weak inhibitors of the enzyme and have been used as templates for the design of peptidomimetic inhibitors. Automated solid-phase synthesis of a small library of compounds based on such a peptidomimetic scaffold has led to the identification of potent and highly selective inhibitors of the NS3 protease enzyme.
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