Related Experiment Video

Updated: Aug 3, 2026

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

The molecular effects of oncogenesis on cell-extracellular matrix adhesion (review)

L Nadav1, B Z Katz

  • 1The Hematology Institute, Tel-Aviv Sourasky Medical Center, 6 Weizman Street, Tel-Aviv 64269, Israel.

International Journal of Oncology
|July 11, 2001
PubMed

Insights

Cell adhesion regulates cell behavior through tyrosine phosphorylation. Oncogenes and tumor suppressors like PTEN impact this signaling, offering therapeutic targets for cancer.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Biochemistry

Background:

  • Cell-extracellular matrix (ECM) interactions are crucial for cellular regulation.
  • Adhesion-mediated signaling, particularly tyrosine phosphorylation, influences cell behavior and cytoskeletal dynamics.
  • Aberrant cell-ECM interactions are implicated in oncogenesis.

Purpose of the Study:

  • To review the direct effects of oncogenes and tumor suppressor genes on cell adhesion.
  • To elucidate the molecular mechanisms linking these genes to adhesion-mediated signaling.
  • To explore therapeutic potential for controlling pathological cell-ECM interactions.

Main Methods:

  • Literature review focusing on molecular mechanisms of cell adhesion signaling.
  • Analysis of the roles of specific oncogenes (e.g., v-Src, BCR/Abl) and tumor suppressors (e.g., PTEN).
  • Examination of tyrosine phosphorylation events in adhesion-mediated signaling pathways.

Main Results:

  • Cell adhesion initiates tyrosine phosphorylation crucial for signaling and cytoskeletal rearrangement.
  • Oncogenes like v-Src and BCR/Abl constitutively activate kinases, affecting signaling molecules and integrin function.
  • The tumor suppressor PTEN is identified as a key regulator of adhesion-mediated signaling.

Conclusions:

  • Oncogenes and tumor suppressors directly modulate cellular adhesive responses.
  • Understanding these molecular effects is key to developing therapeutics for diseases involving abnormal cell-ECM interactions.
  • Targeting adhesion-mediated signaling pathways presents a promising strategy for cancer therapy.

More Related Videos

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay07:21

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay

Published on: December 26, 2019

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment10:39

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment

Published on: May 24, 2022

Related Concept Videos

The Extracellular Matrix01:42

The Extracellular Matrix

In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...