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Updated: Aug 1, 2026
16:56
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
[Should school children receive pertussis vaccine?]
S Sandbu1, H Nøkleby, O S Helland
1Avdeling for vaksine, Statens institutt for folkehelse, Postboks 4404 Nydalen, 0403 Oslo. synne.sandbu@folkehelsa.no
Summary
A booster vaccine dose in early school years can improve diphtheria and pertussis immunity in Norwegian children. This strategy offers better protection without significant side effects, addressing declining vaccine immunity.
Area of Science:
- Pediatric Infectious Diseases
- Vaccinology
- Immunology
Background:
- Norwegian schoolchildren exhibit suboptimal diphtheria immunity before the 11-year booster dose.
- Decreasing vaccine-induced immunity against pertussis observed from age 5-6 years in Norway.
- Need for enhanced immunization strategies against diphtheria and pertussis in early school age.
Purpose of the Study:
- To evaluate the immune response and safety of combined diphtheria, tetanus, pertussis (acellular), and poliomyelitis (DTPa-IPV) vaccine at seven years.
- To assess the immune response and safety of a diphtheria, tetanus, and pertussis (acellular) (DTPa) booster at 11 years.
- To determine the efficacy of early school-age booster doses in improving vaccine immunity.
Main Methods:
- Two parallel trials involving 124 and 83 participants aged seven and 11 years, respectively.
- Administration of DTPa-IPV vaccine at seven years and DTPa vaccine at 11 years.
- Monitoring of immune responses to vaccine components and assessment of adverse events.
Main Results:
- Over 40% of children lacked adequate diphtheria immunity prior to the 11-year booster.
- All participants demonstrated robust immune responses to all vaccine antigens.
- Adverse events were more frequent in 11-year-olds but were transient and not serious.
Conclusions:
- An early school-age booster dose of DTPa-IPV vaccine can enhance protection against diphtheria and pertussis.
- This immunization strategy is well-tolerated and does not result in unacceptable adverse events.
- The findings support the implementation of early booster vaccinations for improved public health.
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