Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroanatomical studies on bipolar disorder.

B Baumann1, B Bogerts

  • 1Department of Psychiatry, University of Magdeburg, Germany. baumann@medizin.uni-magdeburg.de

The British Journal of Psychiatry. Supplement
|July 14, 2001
PubMed
Summary

Mood disorders like bipolar disorder show subtle brain structural changes. Postmortem studies reveal alterations in basal ganglia, locus caeruleus, and dorsal raphe, impacting neurotransmitter synthesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Psychiatric diagnosis system for classification of terroristic perpetrators of violence insufficient].

Der Nervenarzt·2020
Same author

[Psychiatric aspects of terrorism].

Der Nervenarzt·2020
Same author

Updating genome annotation for the microbial cell factory Aspergillus niger using gene co-expression networks.

Nucleic acids research·2018
Same author

Corrigendum to "Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula" [Schizophr. Res. 2016 Nov;177(1-3):52-58].

Schizophrenia research·2018
Same author

Nucleus Accumbens Deep Brain Stimulation for Alcohol Addiction - Safety and Clinical Long-term Results of a Pilot Trial.

Pharmacopsychiatry·2016
Same author

Assessment of Pharmacological Treatment Quality: Comparison of Symptom-triggered vs. Fixed-schedule Alcohol Withdrawal in Clinical Practice.

Pharmacopsychiatry·2016

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurobiology

Background:

  • Neuroimaging reveals structural and functional brain abnormalities in mood disorders.
  • These findings suggest underlying neurohistological alterations contributing to observed macropathology.

Purpose of the Study:

  • To review recent postmortem studies on affective disorders.
  • Focus on identifying neurohistological changes in bipolar disorder.

Main Methods:

  • Comprehensive literature review of postmortem studies.
  • Analysis of volumetric, cyto-architectural, and immunohistochemical data.

Main Results:

  • Smaller basal ganglia observed in depression, regardless of polarity.
  • Increased neuron count in the locus caeruleus in bipolar disorder versus unipolar depression.

Related Experiment Videos

  • Structural deficits in the dorsal raphe in both bipolar and unipolar disorders, suggesting reduced noradrenaline and serotonin synthesis, potentially compensated by antidepressants.

    • Conclusions:

    • Mood disorders may involve subtle structural brain abnormalities contributing to pathogenesis.
    • These histological findings complement observed functional dysregulation.