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Botulinum toxin treatment for cricopharyngeal dysfunction.
1Voice and Swallowing Laboratory, Research Medical Center, Kansas City, Missouri 64131, USA. gshaw@kcnet.com
Dysphagia
|July 17, 2001
Summary
Botulinum toxin A injections effectively improved swallowing in patients with cricopharyngeal muscle (CPM) hypertonicity and spasticity. This treatment showed greater benefits for those with isolated CPM or cranial nerve X dysfunction.
Area of Science:
- Otolaryngology
- Gastroenterology
- Neurology
Background:
- Cricopharyngeal muscle (CPM) hypertonicity/spasticity causes dysphagia, impacting bolus passage.
- Previous treatments include dilation and myotomy.
- Botulinum toxin A injections show promise but require further study.
Purpose of the Study:
- To evaluate the efficacy of botulinum toxin A injections for CPM dysfunction.
- To assess swallowing improvements using patient and objective measures.
Main Methods:
- 12 subjects with CPM dysfunction received botulinum toxin A injections.
- Evaluations included patient symptom ratings, modified barium swallow studies, and manometry.
- Pre- and post-treatment data were analyzed.
Main Results:
- Botulinum toxin A significantly improved swallowing function.
- Patient and investigator ratings indicated enhanced bolus passage.
- Greater improvement observed in isolated CPM or cranial nerve X dysfunction.
Conclusions:
- Botulinum toxin A is an effective treatment for dysphagia due to CPM hypertonicity/spasticity.
- Treatment outcomes correlate with the specificity of the underlying dysfunction.