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The aurosome.

F N Ghadially

    The Journal of Rheumatology. Supplement
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Aurosomes, which are lysosomal bodies containing gold, exhibit distinct electron-dense granules and profiles. Their morphology is consistent across different gold salts, administration routes, species, and cell types, indicating reliable gold detection.

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    Area of Science:

    • Cell Biology
    • Toxicology
    • Materials Science

    Background:

    • Aurosomes are intracellular structures identified in lysosomes, containing gold particles.
    • Gold compounds have been utilized in therapeutic applications, necessitating an understanding of their cellular interactions.
    • The precise morphology and composition of aurosomes require detailed characterization for diagnostic and research purposes.

    Purpose of the Study:

    • To investigate and describe the characteristic morphology of aurosomes formed by different gold preparations.
    • To determine the consistency of aurosome morphology across various administration routes, species, and cell types.
    • To identify the cellular localization of gold deposits in tissues relevant to gold therapy.

    Main Methods:

    • Transmission electron microscopy was employed to examine the ultrastructure of aurosomes.

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  • Aurosomes were analyzed from samples treated with colloidal gold and various soluble gold salts.
  • Cellular and tissue samples from different species and administration routes were compared.

    • Main Results:

    • Colloidal gold produced aurosomes with spherical, electron-dense granules.
    • Soluble gold salts resulted in aurosomes with lamellar, filamentous, and rod-like profiles containing particles and granules.
    • Aurosome morphology, particularly the electron-dense gold deposits, remained consistent irrespective of the gold salt, administration route, species, or cell type.
    • Characteristic electron-dense gold deposits were observed in dermal macrophages (skin) and lysosomes in rheumatoid synovial membranes.

    Conclusions:

    • Aurosomes display distinctive morphologies depending on the type of gold administered (colloidal vs. soluble).
    • The electron-dense content indicative of gold within aurosomes exhibits a remarkably constant morphology.
    • This consistent morphology aids in the identification and characterization of gold deposition in biological tissues.