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A perspective on tropical sprue
1Infectious Diseases Division, Naval Medical Center, San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134-1005, USA. mllim@nmcsd.med.navy
Abstract:
A diagnosis of tropical sprue, an infrequent affliction of inhabitants and travelers in tropical regions, should be considered in patients with a compatible history, malabsorption, and chronic diarrhea. It can occur in either endemic or epidemic form and can be preceded by acute gastroenteritis. The cause of tropical sprue is still unknown, although most data support an infectious etiology. Therapeutic experience is greatest with folic acid and tetracycline. Most patients can be expected to recover with proper nutritional support, although relapses and slow responses occur.
Insights
Tropical sprue is a malabsorption disorder in tropical regions. Diagnosis involves compatible history, malabsorption, and chronic diarrhea, with infectious causes suspected and treatment including nutritional support, folic acid, and tetracycline.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Tropical Medicine
Background:
- Tropical sprue is an uncommon condition affecting individuals in tropical climates.
- It presents with malabsorption and chronic diarrhea, potentially following acute gastroenteritis.
- The condition can manifest in endemic or epidemic patterns.
Purpose of the Study:
- To outline the diagnostic considerations for tropical sprue.
- To review the suspected etiology and therapeutic approaches.
- To describe the typical patient outcomes.
Main Methods:
- This review synthesizes current knowledge on tropical sprue.
- Diagnostic criteria include clinical presentation, history, and evidence of malabsorption.
- Treatment strategies and expected responses are discussed.
Main Results:
- The exact cause remains unknown, but an infectious origin is favored.
- Effective treatments include nutritional support, folic acid, and tetracycline.
- Most patients achieve recovery, though relapses and slow responses are possible.
Conclusions:
- Tropical sprue requires consideration in patients with chronic diarrhea and malabsorption in endemic areas.
- Prompt diagnosis and appropriate management, including nutritional support and antibiotics, are crucial.
- While recovery is common, long-term monitoring may be necessary due to potential relapses.