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Updated: Aug 10, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
Evaluation of model solvent systems for assessing the accumulation of container extractables in drug formulations
1Center for Physical and Chemical Sciences, Baxter Healthcare Inc., William Graham Science Center, Round Lake, IL 60073, USA. dennis_jenke@baxter.com
Abstract:
The interaction between a medical device and a pharmaceutical solution it contacts may dictate solution safety and/or efficacy. Of specific concern is the ability of device components to leach into the contacting solution. As pharmaceutical solutions containing surfactants, co-solvents and solubilizing agents become more common, method's for assessing the extent of leaching are needed. In this manuscript, a model is developed which relates a solution's polarity to its ability to interact with a plastic material. The validity of the developed model is examined via direct analysis of several pharmaceutically relevant solutions.
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