Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dermal neurovascular dysfunction in type 2 diabetes.

A I Vinik1, T Erbas, T S Park

  • 1Department of Medicine and Pathology/Anatomy/Neurobiology, the Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, Virginia, USA.

Diabetes Care
|July 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Osteosarcopenia in acromegaly: reduced muscle quality and increased vertebral fat deposition.

Journal of endocrinological investigation·2023
Same author

The efficacy of pregabalin for treating pain associated with diabetic peripheral neuropathy in subjects with type 1 or type 2 diabetes mellitus.

Current medical research and opinion·2018
Same author

Alternative Quantitative Tools in the Assessment of Diabetic Peripheral and Autonomic Neuropathy.

International review of neurobiology·2016
Same author

Genetic Alterations in Differentiated Thyroid Cancer Patients with Acromegaly.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2015
Same author

Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab).

Journal of the peripheral nervous system : JPNS·2014
Same author

Etiology of hypopituitarism in tertiary care institutions in Turkish population: analysis of 773 patients from Pituitary Study Group database.

Endocrine·2013
Same journal

Type 1 Diabetes Driven by Residual Recipient T Cells After Hematopoietic Cell Transplantation: A Case Report.

Diabetes care·2026
Same journal

Predicting the Path to Attrition: Multidomain Risk Assessment in Diabetic Foot Ulcer Offloading Randomized Controlled Trials.

Diabetes care·2026
Same journal

Habituation to Elevated Glucose Levels in Type 1 Diabetes: Function and Well-Being in Guideline-Based Versus Typical Glycemic Range.

Diabetes care·2026
Same journal

The Correlation Between Fear and Perceived Frequency of Hypoglycemia and Continuous Glucose Monitoring Metrics in Adults With Type 1 Diabetes Using Diabetes Technology: A One-Year Analysis.

Diabetes care·2026
Same journal

A Secular Increase in the Incidence of Islet Autoimmunity Among Colorado Children With Moderate-Risk HLA Genotypes.

Diabetes care·2026
Same journal

Clinical and Biochemical Recovery From Immune Checkpoint Inhibitor-Induced Diabetes With Seroconversion of GAD Antibodies.

Diabetes care·2026
See all related articles

Dermal neurovascular dysfunction is linked to type 2 diabetes and metabolic syndrome. This skin blood flow defect, detectable early, involves C-fiber dysfunction and may be a key component of metabolic syndrome.

Area of Science:

  • Endocrinology
  • Neuroscience
  • Vascular Biology

Background:

  • Metabolic syndrome and type 2 diabetes are associated with various complications.
  • Dermal neurovascular function plays a role in regulating skin blood flow.

Purpose of the Study:

  • To review evidence linking dermal neurovascular dysfunction to metabolic syndrome and type 2 diabetes.
  • To explore the role of skin blood flow regulation in metabolic disorders.

Main Methods:

  • Review of existing data on dermal neurovascular function.
  • Utilizing laser Doppler techniques to measure skin blood flow.
  • Analysis of factors influencing skin vasodilation.

Main Results:

  • Dermal neurovascular dysfunction is identified in most type 2 diabetes patients.

Related Experiment Videos

  • The defect is detectable before diabetes onset and partially reversible with insulin sensitizers.
  • This dysfunction is linked to C-fiber impairment and metabolic syndrome components, involving an imbalance of vasodilators and vasoconstrictors.

    • Conclusions:

    • Dermal neurovascular function, regulated by C-fiber neurons, may be a component of metabolic syndrome in type 2 diabetes.
    • Dysregulation of skin blood flow is a potential marker for metabolic complications.