Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structured disorder and conformational selection.

C J Tsai1, B Ma, Y Y Sham

  • 1Intramural Research Support Program-Science Application International Corporation (SAIC), Laboratory of Experimental and Computational Biology, NCI-Frederick, Frederick, Maryland, USA.

Proteins
|August 3, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of flavonol 3-O-glucosyltransferase activity confers soybean resistance to leaf-chewing insects.

The Plant journal : for cell and molecular biology·2026
Same author

Dual-Network Silk Fibroin/Quercetin Hydrogel for Periodontitis Treatment.

Journal of dental research·2026
Same author

Non-ideal penetration of shaped charge jet into spaced plate based on drift velocity and gap effects.

Scientific reports·2026
Same author

Loss of tight junction protein claudin 18 uncovers alveolar epithelial stem cell plasticity and emergence of non-fibrogenic transitional progenitors.

bioRxiv : the preprint server for biology·2025
Same author

Clinicopathological features and prognosis of patients with colorectal Mucinous adenocarcinoma mixed with other pathological components: a nationwide retrospective study in China.

Techniques in coloproctology·2025
Same author

Performance of machine learning algorithms in predicting the need for surgical fixation in pediatric craniomaxillofacial trauma.

International journal of oral and maxillofacial surgery·2025
Same journal

BioMatics 1.0: A Wasserstein Distance Approach for Next-Generation Multiple Sequence Alignment.

Proteins·2026
Same journal

Engineered HSP90-MP65 Bivalent Fusion Antigen: A Novel Vaccine Candidate Against Invasive Candidiasis.

Proteins·2026
Same journal

Physics-Based Energy Functions for Computational Protein Design.

Proteins·2026
Same journal

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides.

Proteins·2026
Same journal

Stabilization of Bone Morphogenetic Protein-2 at Physiological pH: Contrasting Roles of CHAPS and Arginine in Aggregation Inhibition.

Proteins·2026
Same journal

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase.

Proteins·2026
See all related articles

Molecular disorder arises from rugged energy landscapes, creating functional conformers. This study classifies disordered molecules into two types based on hydrophobic core presence, impacting their experimental detection and protein folding pathways.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Protein Dynamics

Background:

  • Molecular disorder traditionally viewed as instability, hindering atomic coordinate determination.
  • Disordered molecules exhibit prevailing conformations with higher population times.
  • Rugged energy landscapes drive the formation of structured conformers for molecular association.

Purpose of the Study:

  • To re-evaluate the concept of molecular disorder beyond simple instability.
  • To classify disordered molecules into distinct types based on structural characteristics.
  • To elucidate the functional implications of molecular disorder in protein folding and binding.

Main Methods:

  • Classification of disordered molecules into two types based on hydrophobic core presence.

Related Experiment Videos

  • Analysis of population times and experimental detectability of native conformations.
  • Correlation of disordered molecule types with protein folding stages (molten globule to native state).

    • Main Results:

    • Type I disordered molecules possess a hydrophobic core, allowing experimental detection of native conformations.
    • Type II disordered molecules lack a hydrophobic core, resulting in shorter population times and hindered detection.
    • A hydrophobicity function can distinguish between the two disordered molecule types.

    Conclusions:

    • Molecular disorder is functionally significant, generating diverse conformers for biological processes.
    • Type I disorder relates to the molten globule to native state transition; Type II relates to the denatured to native state transition.
    • Protein design strategies can target specific electrostatic and hydrophobic interactions to modulate disorder and control folding pathways.