Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Second-trimester biochemical screening.

M I Evans1, J E O'Brien, E Dvorin

  • 1Department of Obstetrics and Gynecology and Fetal Therapy Program, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania, USA.

Clinics in Perinatology
|August 14, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum: Measurement of the Sixth-Order Cumulant of Net-Proton Multiplicity Distributions in Au+Au Collisions at sqrt[s_{NN}]=27, 54.4, and 200 GeV at RHIC [Phys. Rev. Lett. 127, 262301 (2021)].

Physical review letters·2025
Same author

Effectiveness of quality improvement collaboratives in improving clinical processes and patient outcomes in stroke care.

British journal of neuroscience nursing·2024
Same author

Poisoning by Opium.

The Chicago medical journal·2023
Same author

Musk in Hiccough.

The Chicago medical journal·2023
Same author

Introductory to Lectures on Philosophy of Medicine, in the Spring Course of Rush Med. College, March 8, 1872.

The Chicago medical journal·2023
Same author

To Prevent Rotation in Fracture of the Femur, Etc.

The Chicago medical journal·2023
Same journal

Breathing Physiology into the Art of Neonatal Respiratory Care.

Clinics in perinatology·2026
Same journal

The Science and Art of Neonatal Respiratory Care.

Clinics in perinatology·2026
Same journal

Ex Utero Artificial Womb Support: Promising Future for Extremely Preterm Infants.

Clinics in perinatology·2026
Same journal

Advances in the Use of Cell-Based Therapies for Prevention of Bronchopulmonary Dysplasia.

Clinics in perinatology·2026
Same journal

Evaluation and Management of Genetic Respiratory Disorders Presenting as Hypoxemic Respiratory Failure in the Newborn Infant.

Clinics in perinatology·2026
Same journal

Modern Surfactant Delivery Methods with a Focus on Implementation of Surfactant Administration Through Laryngeal and Supraglottic Airways.

Clinics in perinatology·2026
See all related articles

Biochemical screening shows multiple markers, like beta-hCG, improve detection over AFP alone. Current methods plateau, necessitating new approaches for enhanced screening sensitivity and reduced false positives.

Area of Science:

  • Biochemistry
  • Medical Diagnostics
  • Screening Methodologies

Background:

  • Biochemical screening has advanced, with multiple markers like beta-hCG demonstrating superiority over single markers such as AFP.
  • Controversy persists regarding optimal mathematical algorithms and marker combinations (e.g., beta-hCG, uE3) for screening.
  • Current screening methodologies appear to have reached a plateau in detection frequencies, typically between 65% and 70%.

Purpose of the Study:

  • To review the progress and limitations of current biochemical screening methods.
  • To highlight the need for novel approaches to improve screening sensitivity.
  • To explore the integration of biochemical and biophysical parameters for advanced abnormality detection.

Main Methods:

  • Analysis of existing data on biochemical screening markers.

Related Experiment Videos

  • Discussion of mathematical algorithms used in screening.
  • Exploration of combined biochemical and biophysical parameter approaches.

    • Main Results:

    • Multiple markers, particularly beta-hCG, offer advantages over single markers like AFP.
    • Detection rates for current methods are limited, reaching a plateau around 65-70%.
    • Combining biochemical and biophysical parameters is proposed as a next-generation approach.

    Conclusions:

    • Substantial improvement in screening sensitivity requires innovative approaches beyond current methodologies.
    • The combination of biochemical and biophysical parameters represents a promising strategy for enhancing abnormality detection.
    • Future research should focus on integrating diverse parameters to minimize false positives and maximize detection rates.