Related Experiment Video
Updated: Oct 5, 2026
Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
Published on: July 6, 2014
[Determination of serum cytokines in individuals with HCV infection]
1Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Changsha 410008, China.
Objective:
To investigate the immunopathogenesis of chronic hepatitis C virus (HCV) infection.
Methods:
Serum T-helper lymphocyte (Th1) cytokines (IFN-gamma, IL-2) and Th2 cytokines (IL-4, IL-10) were measured by ELISA in 18 individuals with chronic HCV infection 10 persons of chronic HBV infection and 11 normal persons.
Results:
IL-2 (P <0.05), IL-4 and IL-10 (P <0.025, P <0.001) were significantly increased in HCV infected hosts as compared to 11 normal controls, the production of Th2 cytokines was more predominant.
Conclusions:
An enhanced Th2 responses is present in HCV infection, which may he responsible for the chronicity of HCV infection.
