[Advances in the expression of foreign genes in Hansenula polymorpha]

Hansenula polymorpha is a potential host for foreign gene expression, which has been applied widely in academic studying and industry application. It has a number of advantages of expressing genes derived from eukaryotic organisms, such as mitotically stable recombinant strains, faithful processing of the produced polypeptides, and high productivity et al. Numerous foreign proteins with high commercial value have been expressed successfully in H. polymorpha, among which some have been launched on the market. In this review, the favorable characteristics of this system for foreign gene production and new advances are described.