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Cytotoxicity of Ganoderma lucidum triterpenes
1Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, 701, Republic of China. tswu@mail.ncku.edu.tw
Journal of Natural Products
|August 25, 2001
Abstract:
Two new triterpenoids, lucidenic acid N (1) and methyl lucidenate F (2), together with four known compounds, lucidenic acid A, lucidenolactone, lucidenic acid C, and ganoderic acid E, were isolated from the dried fruiting bodies of Ganoderma lucidum. Their structures were elucidated by spectral and chemical transformation studies. Among them, lucidenic acid N (1), lucidenic acid A, and ganoderic acid E showed significant cytotoxic activity against Hep G2, Hep G2,2,15, and P-388 tumor cells.