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Related Experiment Videos

Phase separated membrane bioreactor: results from model system studies.

G R Petersen1, P K Seshan, E H Dunlop

  • 1Jet Propulsion Laboratory, Pasadena, CA 91109.

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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This study evaluates a novel bioreactor for high-intensity oxygen transfer in microgravity. The design successfully supported Saccharomyces cerevisiae growth, demonstrating its potential for space-based cell culture applications.

Area of Science:

  • Biotechnology
  • Bioreactor Design
  • Microgravity Life Support

Background:

  • Developing efficient bioreactors is crucial for sustaining life in microgravity environments.
  • Oxygen and carbon dioxide transfer are critical parameters for cell culture in space.
  • Current bioreactor designs face challenges in mass transfer efficiency under microgravity.

Purpose of the Study:

  • To describe the operation and evaluation of a novel bioreactor for high-intensity oxygen transfer.
  • To assess the mass transfer characteristics of the bioreactor in a simulated microgravity environment.
  • To demonstrate the bioreactor's capability to support cell growth.

Main Methods:

  • A zero-headspace liquid phase bioreactor separated by silicone rubber tubing was designed.
Keywords:
NASA Center JPLNASA Discipline Life Support SystemsNASA Discipline Number 00-00NASA Discipline Number 61-10NASA Program CELSSNASA Program Flight

Related Experiment Videos

  • Mass transfer studies were conducted to analyze oxygen and carbon dioxide diffusion.
  • Cell growth experiments were performed using Saccharomyces cerevisiae.

    • Main Results:

    • Oxygen transfer was found to be film diffusion controlled, both externally and internally to the tubing.
    • Diffusion across the silicone rubber tube walls was not the rate-limiting factor.
    • Successful cell growth of Saccharomyces cerevisiae was achieved in the bioreactor.

    Conclusions:

    • The developed bioreactor concept is capable of sustaining cell growth in simulated microgravity.
    • Proposed design upgrades aim to eliminate identified mass transfer resistances.
    • This technology holds promise for future space exploration and long-duration missions.