Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

86.5K
Overview
86.5K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.8K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.8K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

16.8K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.8K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

4.5K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
4.5K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

10.1K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
10.1K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

18.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
18.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Economic evaluation of the eradication program for bovine viral diarrhea in the Swiss dairy sector.

Preventive veterinary medicine·2017
Same author

A matched case-control study comparing udder health, production and fertility parameters in dairy farms before and after the eradication of Bovine Virus Diarrhoea in Switzerland.

Preventive veterinary medicine·2017
Same author

A multiarm randomized field trial evaluating strategies for udder health improvement in Swiss dairy herds.

Journal of dairy science·2014
Same author

[Cost-benefit analysis of an intervention to improve udder health in Swiss dairy farms].

Schweizer Archiv fur Tierheilkunde·2014
Same author

Basal cell carcinomas in a tertiary referral centre: a systematic analysis.

The British journal of dermatology·2014
Same author

Missed epidemics and missing links: international birth cohort trends in multiple sclerosis.

European journal of neurology·2012
Same journal

Foreword.

Immunology today·2020
Same journal

The origin and significance of anti-DNA antibodies.

Immunology today·2014
Same journal

Mutations of class II MHC molecules.

Immunology today·2014
Same journal

Antigen processing at the molecular level.

Immunology today·2014
Same journal

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

Immunology today·2014
Same journal

Are MHC class II-restricted cytotoxic T lymphocytes important?

Immunology today·2014
See all related articles

Related Experiment Video

Updated: Apr 4, 2026

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

32.6K

Lymphocyte reactivity during spaceflight.

A Cogoli1, A Tschopp

  • 1Laboratorium für Biochemie, ETH-Zentrum, Zürich, Switzerland.

Immunology Today
|January 1, 1985
PubMed
Summary
This summary is machine-generated.

Spaceflight causes physiological changes, including reduced lymphocyte reactivity. This study investigated immune alterations in astronauts after the Spacelab 1 mission, focusing on immune cell function in microgravity.

More Related Videos

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
11:08

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

12.9K
Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
09:28

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

3.8K

Related Experiment Videos

Last Updated: Apr 4, 2026

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

32.6K
Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
11:08

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

12.9K
Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
09:28

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

3.8K

Area of Science:

  • Space Medicine
  • Immunology
  • Space Physiology

Background:

  • Spaceflight is feasible, but physiological changes can impact crew performance.
  • Known effects include vestibular, cardiovascular, bone, and red blood cell alterations.
  • Immunological alterations are also observed post-flight.

Purpose of the Study:

  • To investigate immunological alterations in space crews.
  • Specifically, to examine the reduction in lymphocyte reactivity to mitogens during the Spacelab 1 mission.

Main Methods:

  • Investigated lymphocyte reactivity to mitogens.
  • Conducted during the Spacelab 1 mission (November 28 - December 8, 1983).

Main Results:

  • Observed a reduction in lymphocyte reactivity to mitogens in space crews post-flight.
  • This immune alteration was a key finding during the Spacelab 1 mission.

Conclusions:

  • Spaceflight is associated with reduced lymphocyte reactivity.
  • Further research is needed to understand the full impact of microgravity on the immune system.