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Related Experiment Videos

Methamphetamine effects on cognitive processing during extended wakefulness.

D A Wiegmann1, R R Stanny, D L McKay

  • 1Naval Aerospace Medical Research Laboratory, Pensacola, Florida, USA.

The International Journal of Aviation Psychology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

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D-methamphetamine (d-methamphetamine HCl) improved vigilance and tracking performance during sleep loss. Higher doses showed longer-lasting effects, reducing sleepiness without increasing impulsive responses.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Human Performance

Background:

  • Sleep deprivation significantly impairs cognitive functions, including vigilance and tracking.
  • Sustained performance tasks are crucial for assessing cognitive resilience under stress.
  • Stimulant medications are often investigated for their potential to counteract performance deficits.

Purpose of the Study:

  • To evaluate the efficacy of two d-methamphetamine HCl doses (5 mg and 10 mg/70 kg) in mitigating performance decrements during sleep loss.
  • To assess the impact of d-methamphetamine on vigilance, tracking performance, and subjective sleepiness.
  • To determine the duration of action for different d-methamphetamine doses.

Main Methods:

  • A double-blind, placebo-controlled study involving 30 participants undergoing a 13.5-hour sustained performance session.

Related Experiment Videos

  • Administration of either 5 mg/70 kg d-methamphetamine, 10 mg/70 kg d-methamphetamine, or placebo.
  • Objective performance measures (vigilance, tracking error) and subjective ratings (sleepiness, sleep latency) were recorded.

    • Main Results:

    • Placebo group performance degraded significantly over the testing period.
    • Both d-methamphetamine doses improved vigilance and tracking performance, reversing initial declines and errors within 3 hours.
    • The 10-mg dose exhibited longer-lasting effects compared to the 5-mg dose, which diminished by 6.5 hours post-administration.

    Conclusions:

    • D-methamphetamine HCl effectively counteracts performance impairments associated with acute sleep deprivation.
    • Dose-dependent effects were observed, with higher doses providing sustained benefits.
    • The findings suggest potential therapeutic applications for d-methamphetamine in managing fatigue-related performance deficits, without increasing impulsivity.