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Published on: March 13, 2015
[Type-specific antibodies to hepatitis C virus in sera from patients with various hematologic diseases]
T A Garanzha1, T A Tupoleva, A A Guliaeva
1Hematological Research Center of the Russian Acad. Med. Sci., Ivanovsky Research Institute of Virology, Moscow, Russia.
Abstract:
The reactivity of 100 sera taken from patients with different blood diseases and donors with respect to synthesized peptides in the variable area of protein NS4 of hepatitis C virus was studied. The presence of type-specific antibodies in the blood sera of patients with hepatitis C was shown. Two antigenic determinant corresponding to 1683-1705 and 1711-1732 amino acid residues in the protein area under study were detected. In hematological patients undergoing frequent blood transfusions mixed infection with different types of hepatitis C virus was registered; these types could be reliably determined with the use of synthetic peptides. The serotype determined with the use of peptides corresponded to the type of the circulating virus.
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