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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Incorporation of positively charged deoxynucleic S-methylthiourea linkages into oligodeoxyribonucleotides
1Department of Chemistry and Biochemistry, University of California, Santa Barbara, 93106, USA.
Bioorganic & Medicinal Chemistry Letters
|September 11, 2001
Abstract:
Oligodeoxyribonucleic acids (15- and 18-mers) containing both negatively charged phosphate and positively charged S-methyl thiourea internucleoside linkages (DNmt/DNA chimera) have been synthesized. DNA binding characteristics and nuclease resistance of DNmt/DNA chimera have been evaluated.
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