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[Effect of metal ions on Escherichia coli NAT 99-50R penicillin acylase production]
N N Aleksakhina1, I A Basnak'ian, N B Romanova
1Mechnikov Research Institute for Vaccines and Sera, Central Research Institute of Medical Technology and Transfusion Medicine, Moscow, Russia.
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|September 12, 2001
Abstract:
The processes of growing E. coli NAT 99-50R in a synthetic nutrient medium containing metal salts (iron nitrate, lutecium nitrate or cerium nitrate) were carried out. As shown in experiments, the addition of metal salts at different concentrations into the medium produced different impact on the penicillinase activity of the culture. This activity increased 7- to 10-fold when the bacteria were grown in a synthetic medium with iron nitrate added at a concentration of 0.0001% or with lutecium nitrate added at a concentration of 0.01%.