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"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains
E Lobatón1, S Velázquez, M J Pérez-Pérez
1Instituto de Química Médica (C.S.I.C.), Madrid, Spain.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
A "second generation" of TSAO molecules directed against TSAO-resistant strains have been prepared. The presence of two neighboring carbonyl groups at the 4" position of the 3'-spiro moiety seems to be important for the anti-HIV-1 activity against both wild type and TSAO-resistant strains. NMR conformational studies in solution and theoretical calculations of the novel compounds have also been carried out.