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4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family
E Lobatón1, S Velázquez, A San-Félix
1Instituto de Química Médica (C.S.I.C.), Madrid, Spain.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
The first TSAO derivative that lacks the amino group at the 3'-spiro moiety has been prepared. This molecule retained its HIV-1 specificity (NNRTI characteristic) but did not select for any of the classical NNRTI-specific mutations in the NNRTI binding pocket, including 138-Lys (TSAO resistant strain).