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Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?
D Rejman1, J Snásel, R Liboska
1Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.