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Site-directed alkylation to cytidine within duplex by the oligonucleotides containing functional nucleobases

F Nagatsugi¹, T Kawasaki, N Tokuda

¹Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Nucleosides, Nucleotides & Nucleic Acids

|September 21, 2001

Abstract:

We have previously described that oligonucleotides (ODN) containing phenylsulfoxide derivative of 2-amino-6-vinylpurine nucleoside analog (1) are activated within duplex to form cross-link toward cytidine selectively at the target site. In this paper, we wish to report the search for more stable precursor susceptible for activation within duplex.

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