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Efficient cross-linking to cytidine under neutral conditions using the 2-amino-6-vinylpurine derivative having an
F Nagatsugi1, N Tokuda, T Kawasaki
1Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Nucleic Acids Research. Supplement (2001)
|July 3, 2003
Abstract:
We have previously reported that the oligonucleotides incorporating 2-amino-6-vinyl purine analog (1) showed efficient interstrand cross-linking with selectivity toward cytidine at a target site. In this paper, we describe the design of more efficient cross-linking reagent (2) bearing 2-amino-6-vinyl purine motif to react to cytidine selectively under neutral condition.