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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
Human immunodeficiency virus infection and renal failure
1Renal Diseases Division of the State University of New York, Downstate Medical Center, Brooklyn, New York, USA. tksrao@pol.net
Infectious Disease Clinics of North America
|September 26, 2001
Summary
HIV-associated kidney disease is a major health issue, but advancements in antiretroviral therapy are improving patient outcomes and survival rates. Newer treatments offer hope for preventing and managing HIV-related renal complications.
Area of Science:
- Nephrology
- Infectious Diseases
- Virology
Background:
- Renal manifestations are a significant cause of illness and death in individuals with Human Immunodeficiency Virus (HIV).
- Understanding the specific glomerular lesions and their pathogenesis in HIV-associated nephropathy (HIVAN) has advanced considerably.
- Historically, the prognosis for HIV patients with renal failure was poor, leading to reluctance in care.
Purpose of the Study:
- To review the current understanding of renal manifestations in HIV disease.
- To highlight the impact of newer antiretroviral agents on preventing and treating HIV-related kidney disease.
- To discuss the improving survival and quality of life for patients with HIV and kidney disease.
Main Methods:
- Literature review of studies on HIV and renal disease.
- Analysis of trends in patient survival with end-stage renal disease (ESRD) on renal replacement therapy (RRT).
- Evaluation of the impact of modern antiretroviral therapies on renal outcomes.
Main Results:
- Significant progress in identifying glomerular lesions and pathogenesis in HIVAN.
- Newer antiretroviral agents show promise in preventing and treating established HIVAN.
- Survival rates for HIV patients with ESRD receiving RRT are improving.
- Acute, reversible renal failure in hospitalized HIV patients is declining.
Conclusions:
- Physicians are increasingly familiar with and encouraged by favorable outcomes in HIV-related renal disease.
- Expanding knowledge of virology and effective antiretroviral use can further enhance survival and quality of life for HIV patients with renal disease.
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