Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Strand-specific postreplicative processing of mammalian telomeres.

S M Bailey1, M N Cornforth, A Kurimasa

  • 1Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.

Science (New York, N.Y.)
|September 29, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Analysis of posterior uterus approach combined with vascular occlusion in placenta percreta].

Zhonghua fu chan ke za zhi·2026
Same author

[Assessing the accuracy and comprehensiveness of large language models in responding to patient inquiries on placenta accreta spectrum].

Zhonghua yi xue za zhi·2025
Same author

[Analysis of clinical manifestations and genetic characteristics of a late-onset auditory neuropathy pedigree caused by a mitochondrial <i>MT-TS1</i> gene mutation m.7471dup].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same author

[Impact of the number of cesarean deliveries on adverse pregnancy outcomes of cesarean section in a single-center cohort study].

Zhonghua fu chan ke za zhi·2025
Same author

[Changes of hemodynamic parameters in normal pregnant women and their relationship with maternal basic characteristics].

Zhonghua fu chan ke za zhi·2024
Same author

[Clinical analysis of 86 cases of acute fatty liver of pregnancy].

Zhonghua fu chan ke za zhi·2023
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
See all related articles

Telomeres protect chromosome ends. Telomeric repeat binding factor 2 (TRF2) and DNA-dependent protein kinase (DNA-PK) are crucial for telomere function, with TRF2-mediated end-capping occurring post-replication on leading-strand synthesized telomeres.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Telomeres are essential nucleoprotein structures protecting eukaryotic chromosome ends.
  • TRF2 and DNA-PK are vital for maintaining telomere integrity, preventing chromosomal fusion.
  • Loss of TRF2 or DNA-PK activity leads to end-to-end chromosomal fusions.

Purpose of the Study:

  • To investigate the role of TRF2 and DNA-PK in post-replicative telomere processing.
  • To determine if the requirement for TRF2 and DNA-PK is dependent on the mode of DNA replication.

Main Methods:

  • Investigated TRF2 and DNA-PK activity in mammalian cells.
  • Analyzed telomere replication and processing in relation to DNA synthesis strands.

Main Results:

Keywords:
Non-programmatic

Related Experiment Videos

  • TRF2-mediated telomere end-capping occurs after DNA replication.
  • The postreplicative function of TRF2 and DNA-PKcs is specific to telomeres synthesized by the leading strand.
  • A differential postreplicative processing of telomeres based on replication mode was identified.

Conclusions:

  • Telomere replication mode dictates postreplicative processing.
  • TRF2 and DNA-PK play distinct roles in capping leading-strand synthesized telomeres.
  • This highlights a novel mechanism in maintaining genome stability.