Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Device-associated infections: a macroproblem that starts with microadherence.

R O Darouiche1

  • 1Infectious Disease Section and Center for Prostheses Infection, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA. rdarouiche@aol.com

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|September 29, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevention and management of internal cerebrospinal fluid shunt infections.

The Journal of hospital infection·2016
Same author

Spinal and paraspinal pneumococcal infections-a review.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2014
Same author

Efficacy of trypsin in enhancing assessment of bacterial colonisation of vascular catheters.

The Journal of hospital infection·2010
Same author

A bacterial interference strategy for prevention of UTI in persons practicing intermittent catheterization.

Spinal cord·2009
Same author

Prevention of infections associated with vascular catheters.

The International journal of artificial organs·2008
Same author

In-vitro activity and in-vivo efficacy of catheters impregnated with chloroxylenol and thymol against uropathogens.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2007
Same journal

Reconsidering ambiguous language in infectious disease consult recommendations.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Antibiotic Treatment Duration for Uncomplicated Monomicrobial Enterococcal Bloodstream Infection: A Multicenter Target Trial Emulation.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Larger Blood Volume Increases Detection of Fastidious Mycobacteria and Fungi in Blood Culture.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Anticalcitonin: Limited utility of a context-dependent biomarker demonstrated in another real-world data set.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Procalcitonin Testing in Community-Acquired Pneumonia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Wanted: A Relevant Correlate of Protection for Dengue Vaccines.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
See all related articles

Medical devices cause hospital-acquired infections, especially in critically ill patients. Research explores device modifications to prevent bacterial colonization and infection, aiming to reduce patient harm and healthcare costs.

Area of Science:

  • Medical microbiology
  • Biomedical engineering
  • Infectious disease

Background:

  • Medical devices contribute significantly to hospital-acquired infections (HAIs), particularly impacting critically ill patients.
  • Device-associated infections lead to severe medical complications and substantial economic burdens.
  • Bacterial colonization on indwelling devices often precedes infection and device malfunction.

Purpose of the Study:

  • To analyze the pathogenesis of device-associated infections, focusing on bacterial, device, and host interactions.
  • To evaluate the efficacy of traditional preventive strategies, such as antimicrobial coatings.
  • To explore novel approaches for preventing device-associated infections.

Main Methods:

  • Review of existing literature on the pathogenesis of device-associated infections.

Related Experiment Videos

  • Analysis of bacterial factors, device characteristics, and host responses.
  • Evaluation of traditional antimicrobial coating strategies and their clinical outcomes.
  • Consideration of emerging strategies like biofilm modification and bacterial interference.

    • Main Results:

    • Bacterial factors play a crucial role in infection pathogenesis, while device factors offer the most promising targets for prevention.
    • Traditional antimicrobial coatings have shown variable success in preventing device-associated infections.
    • Some bacterial receptors align with the proposed "adherence/infection" postulates, indicating potential targets.

    Conclusions:

    • Device-associated infections pose a significant threat, necessitating innovative prevention strategies.
    • Modifying device factors, rather than solely relying on antimicrobial coatings, holds promise for enhanced prevention.
    • Further investigation into biofilm modification and bacterial interference is warranted to combat device-associated infections effectively.