Related Experiment Videos
Regioselective synthesis of polysubstituted pyrazoles and isoxazoles
A R Katritzky1, M Wang, S Zhang
1Department of Chemistry, University of Canterbury, Christchurch, New Zealand. katritzky@chem.ufl.edu
The Journal of Organic Chemistry
|October 2, 2001
Abstract:
A regioselective synthesis has been developed for the preparation of unsymmetrical 1,3,5-triaryl-4-alkylpyrazolines and -pyrazoles by treatment of alpha-benzotriazolyl-alpha,beta-unsaturated ketones with monosubstituted hydrazines followed by alkylation at the 4-position of the pyrazoline ring. Reaction of alpha-benzotriazolyl-alpha,beta-unsaturated ketones with hydroxylamine gives 3,5-disubstituted isoxazoles regioselectively.