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Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
Published on: May 11, 2015
Molecular genetic analysis of diabetes in mice
1Division of Diabetes and Endocrinology, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232, USA. maureen.gannon@mcmail.vanderbilt.edu
Trends in Genetics : TIG
|October 5, 2001
Abstract:
Transgenic and 'knockout' models are increasingly used to study the role of the immune system, insulin signaling and beta-cell gene transcription in diabetes. Mice and humans have similar genetics, developmental biology and physiology. In interpreting these models, however, one needs to be mindful of some differences that exist between mice and humans.
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