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Updated: Oct 4, 2026
Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium
Published on: July 14, 2020
Electroretinogram contact lens electrode with tri-color light-emitting diode
S Mizunoya1, K Kuniyoshi, M Arai
1Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School and Schepens Retina Associates, Boston, Massachusetts, USA. s-miz@jg7.so-net.ne.jp
Purpose:
This study was performed to evaluate a new electroretinogram (ERG) contact lens electrode containing four light-emitting diodes (LEDs) that are used for both stimulus and background light.
Methods:
The luminance of each LED could be changed independently and used as stimulus light. Red, blue, bright white, and flickering ERGs were recorded in 12 normal subjects and two patients with progressive cone dystrophy. The long-duration light stimuli separated the on- and off-responses of the ERG. This equipment is not according to the ISCEV standard.
Results:
The tri-color LED electrode contact lens can efficiently produce and record ERG responses. Off-responses were recordable separately from on-responses by lengthening the stimulus duration.
Conclusion:
This combined stimulus-electrode system is compact and portable. Combined with the portable amplifier and the recorder, the ERGs can be recorded easily in an operating room, at patients' bedside, and in remote locations away from clinics and hospitals.
