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Related Experiment Videos

Peptide-plane flipping in proteins.

S Hayward1

  • 1Royal Society-Wolfson Bioinformatics Laboratory, School of Information Systems, University of East Anglia, Norwich NR4 7TJ, UK. sjh@sys.uea.ac.uk

Protein Science : a Publication of the Protein Society
|October 18, 2001
PubMed
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Peptide-plane flips are large rotations in protein structures that are crucial for protein folding. This study identified 32 types of flips, with beta-turn interconversions being the most common, impacting protein structure dynamics.

Area of Science:

  • Structural Biology
  • Protein Folding Dynamics
  • Computational Biophysics

Background:

  • Peptide-plane flips involve significant rotations of peptide planes in protein structures.
  • These flips are hypothesized to be important in the initial stages of protein folding.
  • Understanding these conformational changes requires analyzing high-resolution protein structures.

Purpose of the Study:

  • To investigate the phenomenon of peptide-plane flips in proteins.
  • To identify and classify different types of peptide-plane flips.
  • To analyze the role of these flips in protein structural transitions.

Main Methods:

  • Analysis of 76 proteins with available high-resolution X-ray conformations.
  • Identification of peptide-plane flips using changes in phi,psi angles.

Related Experiment Videos

  • Classification of flips based on Ramachandran plot regions (alpha(R), alpha(L), beta, epsilon).

    • Main Results:

    • 23 instances of peptide-plane flips were identified.
    • The most frequent flip observed was the type I to type II beta-turn interconversion.
    • 32 distinct types of peptide-plane flips were cataloged, with 8 classified as 'passive'.

    Conclusions:

    • Peptide-plane flips, particularly beta-turn interconversions, are significant in protein conformational dynamics.
    • Both passive and active flips contribute to structural rearrangements without necessarily altering side-chain orientations.
    • Specific flips, like the alpha(L) to beta conversion, demonstrate concerted movements crucial for protein structure formation.