Related Experiment Videos
Isolated limb perfusion: the European experience
F J Lejeune1, B B Kroon, F Di Filippo
1Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. ferdy.lejeune@chuv.hospvd.ch
Surgical Oncology Clinics of North America
|October 20, 2001
Abstract:
Isolated limb perfusion (ILP) is a method of cancer treatment allowing the administration of high doses of anticancer agents in a limb surgically isolated from systemic circulation. By using continuous leakage monitoring and using the drug melphalan, a high complete remission rate is obtained in patients with melanoma. In patients with sarcomas, ILP with tumor necrosis factor and melphalan represents a neoadjuvant treatment for limb-sparing surgery. This treatment is the first demonstration of an active anti-angiogenic regimen in the clinic.