Related Experiment Video
Updated: Aug 18, 2026

Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein
Published on: December 3, 2010
[The active efflux pump in antimicrobial resistance]
Abstract:
Active efflux of antibiotics is one of the different resistance mechanisms of bacteria against antimicrobial agents. The rapid exit of the antibiotic from the bacteria prevents its interaction with target point. This mechanism, also known as active efflux pump, is very important since it can explain the simultaneous resistance to several antibiotic families. There are four main active efflux systems: MFS, RND, Smr and ABC. This review includes all of them, together with their transporting proteins, the bacteria that have those proteins and the phenotype of the antibiotics affected. The complex genotype regulation systems, including codifying genes, positive and negative regulators, chromosomal or plasmidic localization is also studied. Finally, the causes of marked resistance to antimicrobial agents of isolated strains in the clinic, especially in hospital areas are revised. The role of the European Antimicrobial Resistance Surveillance System (EARSS) in the evaluation of those resistances is discussed.
More Related Videos
Related Concept Videos
ABC Transporters: Exporter
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
Carrier-Mediated Transport
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Active Transport
Primary active transporters, like Na+, K+ and -ATPase, directly utilize ATP to move ions across the membrane. These transporters play significant roles in various physiological processes. For instance, Na+, K+ and -ATPase maintain...
Development of Antibiotic Resistance
Mechanism of Antibiotic Resistance in MRSA

