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Application of Arene-Ruthenium Chemistry to a Formal Total Synthesis of OF 4949 III
Anthony J. Pearson1, Penglie Zhang, Kieseung Lee
1Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106.
The Journal of Organic Chemistry
|September 20, 1996
Abstract:
A convergent formal total synthesis of OF 4949 III is described. Arene-ruthenium chemistry was used in the construction of the diaryl ether linkage in high yield, and cycloamidation under high dilution conditions (0.005 M) was achieved using DPPA as coupling reagent. SmI(2) was used to reductively remove the 2-iodoethyl ester protecting group in the presence of DMPU or HMPA.