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Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Synthesis of a New Ligand for Metal Assembly to a Selective Receptor
Alan W. Schwabacher1, Andrei D. Stefanescu, Atiq ur Rehman
1Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201.
Abstract:
Diarylphosphinic acid 2, bearing two ethylenediamine groups, was designed with the aim of assembly to form a hydrophobic cavity upon binding to metals. The new ligand was prepared in optically active form from phenylalanine by an efficient sequence which required chromatography only for the P-C bond forming steps. Versatile intermediates in the synthesis are described. Complexes of this ligand with Zn(2+) were shown to bind closely related aromatic guests bearing anionic tethered groups with 1000-fold discrimination.
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