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Published on: April 13, 2010
[Risk factors for asthma, allergy and bronchial hyperresponsiveness in children aged 6-8 years old]
C Pardos Martínez1, V López Cortés, E González Pérez-Yarza
1Centro de Salud del Perpetuo Socorro, Huesca, Spain. jfuertesf@medynet.com
Insights
This study identified key risk factors for asthma, allergy, and bronchial hyperresponsiveness in children. Family history of asthma, eczema symptoms, and early childhood bronchitis are significant predictors.
Area of Science:
- Pediatric Allergy and Immunology
- Respiratory Medicine
- Epidemiology
Context:
- Asthma, allergy, and bronchial hyperresponsiveness (BHR) are significant public health concerns in childhood.
- Identifying early risk factors is crucial for timely intervention and prevention strategies.
- This study focuses on a pediatric population in Huesca, Spain, to understand local risk profiles.
Purpose:
- To determine the specific risk factors associated with the development of asthma, allergic diseases, and bronchial hyperresponsiveness in children aged 6-8 years.
- To analyze the association between various factors, including family history, environmental exposures, and early life illnesses, and these respiratory conditions.
Summary:
- A cross-sectional study involving 309 children aged 6-8 years utilized prick tests and bronchial hyperresponsiveness assessments.
- Multivariate analysis revealed that a family history of asthma, cutaneous sensitization to aeroallergens, and recurrent bronchitis in early life are significant risk factors for asthma.
- Risk factors for allergy included atopic dermatitis symptoms, family history of asthma, and male sex, while BHR was associated with recurrent early-life bronchitis, atopic dermatitis, and aeroallergen sensitization.
Impact:
- Provides valuable insights into the multifactorial etiology of pediatric respiratory conditions.
- Findings can inform targeted screening programs and public health initiatives for early detection and prevention.
- Contributes to the understanding of asthma and allergy prevalence and risk factors in a specific European pediatric cohort.
Objective:
To determine risk factors for asthma, allergy and bronchial hyperresponsiveness in children aged 6-8 years old from Huesca (Spain).
Patients And Methods:
Cross-sectional study of asthma, rhinitis and atopic dermatitis, using the prick test and bronchial hyperresponsiveness (free-running test, forced expiratory volume in 1 sec) in a random sample (n = 309) of children aged 6-8 years oldfrom an urban area (n = 1,051). To evaluate differences in the study variables between asthmatics and non-asthmatics, allergic and non-allergic children and BHR-positive and BHR-negative children, a bivariate analysis was performed using the Chi-squared test and Fisher's exact test. Multiple regression analysis was used to study the association between asthma, allergy and BHR and the study variables. Beta-coefficients and their corresponding standard deviations were calculated according to the maximum verisimilitude method using the SPSS program.
Results:
The theoretical sample included 305 children and informed consent was requested from 357 parents or guardians. The participation rate was 86.55 % (n = 309). The results of the multivariate analysis were as follows: (1) risk factors for asthma were a history of asthma in the immediate family (OR: 5.17; 95 % CI: 21.82-1.23), cutaneous sensitization to aeroallergens (OR: 8.49; 95 % CI: 30.52-2.37) and recurrent bronchitis during the first 2 years of life (OR: 4.68; 95 % CI: 17.76-1.24); (2) risk factors for allergy were symptoms of atopic dermatitis (OR: 10.87; 95 % CI: 38.63-3.06), a history of asthma in the immediate family (OR: 6.11; 95 % CI: 27.68-1.38) and male sex (OR: 4.53; 95 % CI: 19.55-1.05); (3) risk factors for BHR were recurrent bronchitis during the first 2 years of life (OR: 4.56; 95 % CI: 20.24-1.02), symptoms of atopic dermatitis (OR: 4.15; 95 % CI: 16.28-1.06) and cutaneous sensitization to aeroallergens (OR: 3.43; 95 % CI: 10.91-1.08).
Conclusions:
The risk factors for asthma, allergy and BHR have been determined in children aged 6-8 years old from Huesca.
Related Concept Videos
Allergic Reactions
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction
Asthma III: Clinical Manifestations

