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Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Related Experiment Video

Updated: Jul 19, 2026

Inducible and Reversible Dominant-negative (DN) Protein Inhibition
08:35

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

Retinoblastoma protein: combating algal bloom.

F R Cross1, J M Roberts

  • 1The Rockefeller University, 1230 York Ave., Box 237, New York, New York 10021,USA. fcross@mail.rockefeller.edu

Current Biology : CB
|October 26, 2001
PubMed
Summary

Researchers discovered a retinoblastoma protein (Rb) homolog in Chlamydomonas algae. This finding offers new insights into Rb

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Eukaryotic Gene Regulation

Background:

  • The retinoblastoma protein (Rb) is a key regulator of the cell cycle in eukaryotes.
  • Understanding Rb's evolutionary conservation and function across diverse organisms is crucial.

Purpose of the Study:

  • To investigate the presence and potential function of Rb homologs in unicellular eukaryotes.
  • To explore novel mechanisms of cell-cycle control.

Main Methods:

  • Bioinformatic analysis to identify potential Rb homologs.
  • Molecular and genetic studies in Chlamydomonas.

Main Results:

  • A functional homolog of the retinoblastoma protein (Rb) was identified in the alga Chlamydomonas.

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Last Updated: Jul 19, 2026

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  • This discovery extends the known evolutionary range of Rb proteins.

    • Conclusions:

    • The presence of an Rb homolog in Chlamydomonas suggests a conserved role in cell-cycle regulation.
    • This finding opens new avenues for studying Rb function in a simplified eukaryotic system.