A skin moisturizing cream containing Quaternium-18-Bentonite effectively improves chronic hand dermatitis

Area of Science:

• Dermatology
• Occupational Health
• Cosmetic Science

Background:

• Chronic hand dermatitis, including irritant and allergic types, presents management challenges, particularly for those with unavoidable occupational exposures.
• Existing protective creams have demonstrated limited efficacy in controlling symptoms.

Purpose of the Study:

• To evaluate the effectiveness of a novel moisturizing cream formulated with Quaternium-18-Bentonite for treating chronic hand dermatitis.
• To assess the cream's impact on occupational hand dermatitis.

Main Methods:

• Adult subjects with chronic hand dermatitis (allergic, irritant, or mixed) applied the study cream over 8 weeks.
• Skin parameters (redness, scaling, fissuring, blistering, pruritus) and global evaluations were assessed numerically by subjects and investigators at 2, 4, and 8 weeks.
• Topical corticosteroid use was recorded; only antihistamines were permitted as systemic therapy.

Main Results:

• A 50% improvement in global evaluations was observed (p < 0.001), with final scores averaging 2.8-2.9 from initial scores of 5.8-6.0.
• Topical corticosteroid use decreased in 29 out of 33 subjects.
• Complete or near-complete skin clearing (score 0-2) was achieved by 15 subjects, with no adverse effects reported.

Conclusions:

• The tested moisturizing cream demonstrated significant improvement in chronic hand dermatitis for a majority of participants.
• The cream offers a viable therapeutic option for individuals with persistent hand dermatitis, even when occupational exposures continue.