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Comparative study of modulatory effects of Semax and primary proline-containing peptides on hemostatic reactions
K A Cherkasova1, L A Lyapina, I P Ashmarin
1Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow. chk99@mail.ru
Bulletin of Experimental Biology and Medicine
|November 1, 2001
Abstract:
Intranasal administration of Semax, peptide Pro-Gly-Pro, and a mixture of peptides Pro-Gly+Gly-Pro to rats for 5 days enhanced anticoagulant and fibrinolytic potential of the plasma (total fibrinolytic activity and plasmin and plasminogen activator activities) and decreased antiplasmin concentration. Semax and Pro-Gly-Pro decreased the weight of thrombi during experimental thrombosis.