Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early nephron formation in the developing mouse kidney.

J B Bard1, A Gordon, L Sharp

  • 1Department of Biomedical Sciences, University of Edinburgh, UK. j.bard@ed.ac.uk

Journal of Anatomy
|November 6, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence and predictors of early gestational weight gain associated with obesity risk in a diverse Australian antenatal population: a cross-sectional study.

BMC pregnancy and childbirth·2017
Same author

False-positive synovial fluid alpha-defensin test in a patient with acute gout affecting a prosthetic knee.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2017
Same author

Rural habitat as risk factor for hepatitis E virus seroconversion in HIV-infected patients: A prospective longitudinal study.

Zoonoses and public health·2017
Same author

EBRA-Digital release 2003 versus 1998: A comparison of instrument repeatability for measuring implant migration and wear.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2017
Same author

Differences in Gut Metabolites and Microbial Composition and Functions between Egyptian and U.S. Children Are Consistent with Their Diets.

mSystems·2017
Same author

Midterm outcome of the plasma cup in total hip arthroplasty.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2017
Same journal

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice.

Journal of anatomy·2026
Same journal

Layer-by-layer soft-tissue effects on flexion-extension-dominant passive ex vivo limb joint ROM in quadrupedal mammals: An anatomical contribution to a morphofunctional framework.

Journal of anatomy·2026
Same journal

Musculo-skeletal variation in the forelimb of two highly specialised diggers (genus Talpa).

Journal of anatomy·2026
Same journal

Computed tomography reveals the endocranial anatomy of Crocodylia: Implications for phylogenetic relationships and ecomorphological convergence across Crocodylomorpha.

Journal of anatomy·2026
Same journal

Growing together: Developmental integration and modularity in the human talus-calcaneus complex.

Journal of anatomy·2026
Same journal

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study.

Journal of anatomy·2026
See all related articles

This study reveals how kidney nephrogenic aggregates form from mesenchyme caps, detailing cell behavior and expression patterns during early kidney development and nephron initiation in mice.

Area of Science:

  • Developmental Biology
  • Renal Physiology

Background:

  • Nephron initiation is a critical process in kidney development.
  • Understanding the cellular origins of nephrons is essential for regenerative medicine and treating kidney diseases.

Purpose of the Study:

  • To elucidate the cellular mechanisms and spatiotemporal dynamics of nephrogenic aggregate formation.
  • To investigate the roles of NCAM and Pax2 in early kidney development.

Main Methods:

  • 3-dimensional confocal microscopy was employed to observe cellular behavior.
  • Immunohistochemistry for NCAM and Pax2 expression was utilized.

Main Results:

  • Nephrogenic aggregates form from NCAM- and Pax2-positive metanephric mesenchyme caps surrounding mouse kidney duct tips.

Related Experiment Videos

  • Cells within these aggregates rapidly epithelialise to form tubules that invade the duct epithelium.
  • Pax2 expression delineates the formation of the nephrogenic blastemal cell rind on the kidney surface.

    • Conclusions:

    • The study refines the understanding of the timing and cellular processes involved in nephron initiation.
    • NCAM and Pax2 play crucial roles in the formation and organization of early nephrogenic structures.