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Raman spectroscopy in ophthalmology: from experimental tool to applications in vivo
R J Erckens1, F H Jongsma, J P Wicksted
1Dept. of Ophthalmology, Academic Hospital Maastricht, Maastricht, PO Box 5800, DOT 10, 6202AZ, The Netherlands.
Lasers in Medical Science
|November 13, 2001
Summary
Raman spectroscopy, a molecular analysis technique, is increasingly used in biomedical and ophthalmology research. Advances enable its application in delicate eye structures, suggesting future clinical use.
Area of Science:
- Biomedical Optics
- Spectroscopy
- Ophthalmology
Background:
- Raman spectroscopy offers molecular composition analysis.
- Instrument advancements allow low light signal detection.
- This enables biomedical and ophthalmic applications.
Purpose of the Study:
- To inventory Raman spectroscopy applications in biomedical science.
- To specifically review its use in ophthalmology.
Main Methods:
- Literature search using Medline, Current Contents, and patent servers.
- Analysis of references from articles and patents.
Main Results:
- Identified diverse Raman techniques and biomedical applications.
- Observed a significant increase in ophthalmology-related articles since the late 1970s.
Conclusions:
- Raman spectroscopy has broad biomedical research applications.
- The growing body of ophthalmology literature indicates potential for future clinical integration.
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